Antibiotics and Anti-inflammatories in Rhino

A postgraduate student of Dr Johan Marais, Marion Leiberich is currently working on the availaibility and effect of an antibiotic and anti-inflammatory in White rhino.

Due to the poaching crisis of White rhinoceros and the increasing need for veterinary interventions for this endangered species, the pressing question about an appropriate antibiotic and anti-inflammatory treatment emerges. So far, no scientifically proven guideline for the use of antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) in rhinoceroses is available.

Does the antibiotic reach a serum concentration considered as a relevant therapeutic level? What is the appropriate administration dose and how long does it remain on a therapeutic level?  Those questions and many more have not yet been answered. However, the right choice of a drug and the appropriate dose shouldn’t remain a matter of guesswork.

For that reason the aim of the study is to evaluate the pharmacokinetics of enrofloxacin and carprofen in White rhinoceros.  Furthermore, the aim is to compare the treatment consisting of the antibiotic and NSAID injection with a treatment combining the injection of enrofloxacin and carprofen with a water-soluble enrofloxacin medication over 72 hours. Hereby, the goal is to provide a dosage recommendation for clinical use in White rhinoceros.